ADC Linker Gly-Gly-Leu CAS 14857-82-0 HPLC 99+

Product Description

ADC Linker Gly-Gly-Leu CAS 14857-82-0 HPLC 99+

Name: Gly-Gly-Leu

CAS NO: 14857-82-0

M.W: 245.28

Appearance: White Powder

HPLC: 99+   

Synonyms: Gly-Gly-Leu

Application

Dipeptide/Tripeptide linkers:

Gly-Gly-Leu is usually combined with a self-immolative spacer (e.g., PABC: para-aminobenzyloxycarbonyl).

General structure:
Antibody – Linker (Gly-Gly-Leu-PABC) – Drug

After enzymatic cleavage, the spacer undergoes self-immolation, releasing the free payload.

Comparison with other linkers:

The most widely used sequence is Val-Cit.

Gly-Gly-Leu provides an alternative with different cleavage kinetics and stability, useful for optimizing ADC design.

Advantages:

Stable in blood circulation (less susceptible to off-target proteases).

Efficiently cleaved in lysosomal environment → selective drug release.

Package

Transportation

Small package(1g, 25g, 1Kg, 25Kg) can be shipped by Express. (DHL, FedEx, EMS, etc.)
Large package(100kg and more than100Kg) can be transported by Air or Sea.

All transportation is in accordance with the customer's needs.

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